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Glyphosate Use and Cancer Incidence in the Agricultural Health Study.

Andreotti et al., Nov 2017

The Agricultural Health Study (AHS) is a ongoing  prospective cohort of licensed pesticide applicators enrolled in Iowa or North Carolina, Note that the authors do not provide data on exposure (no human biomonitoring no ambient monitoring data is collected within the study). The pesticide use data is based on a follow-up questionnaire that was administered five years after enrollment and completed by 63% of the participants.

In the recent data update the authors could not observe associations between glyphosate use and overall cancer risk or total lymphohematopoietic cancers, including NHL and multiple myeloma. However, there was evidence of an increased risk of AML (acute myeloid leukemia) for applicators, particularly in the highest category of glyphosate exposure compared with never users of glyphosate. The authors  truncated cancer incidence follow-up in 2005 to be concurrent with the last exposure information. Based on 26 exposed cases, there was an increased risk of acute myeloid leukemia (AML) compared with never users (RR = 2.44, 95% CI = 0.94 to 6.32, Ptrend = .11), though this association was not statistically significant.

Expeditious efforts to replicate these findings are warranted.

https://academic.oup.com/jnci/advance-article/doi/10.1093/jnci/djx233/4590280