Chronic Obstructive Pulmonary Disease (COPD) is a major and growing disease world-wide  that is not well-recognized and is thus under-diagnosed. It is caused by exposures to a multitude of vapors, gasses, dusts and fumes known collectively as VGDF. Many VGDF exposures found in the workplace and in the environment are not recognized as serious risks and are often unregulated. The Collegium Ramazzini calls on the international community of occupational and environmental safety and health professionals to adopt a new paradigm towards the recognition and prevention of occupational and non-occupational exposures to VGDFs that cause COPD.